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感染科

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施智源 主任

姓名 施智源
現職 感染科科主任
專長 各種感染症與發燒疾病的診斷與治療, 包括細菌、病毒、黴菌、寄生蟲等微生物所造成的感染性疾病,例如腦膜腦炎、肺炎、腸炎、泌尿道感染、蜂窩組織炎、結核病、疫苗注射、性病、愛滋病等。
學歷 臺北醫學院醫學系 1981/9至1988/6
東海大學工業工程與經營資訊學系高階醫務工程與管理碩士班
(2012 / 9至2014/6)
東海大學工業工程與經營資訊學系博士班
(2015/2 迄今)
經歷 臺中榮總 內科部 住院醫師 1989/7至1993/6
臺中榮總 內科部 總醫師 1993/7 至 1994/6
臺中榮總 感染科主治醫師 1994/7至 2002/11 
臺中榮總 感染科科主任 2002/12~迄今
專業證照 內科專科醫師 1993/1/19
感染症專科醫師 1995/1/8
教職 陽明大學 醫學院助理教授 1999/10~迄今
進修訓練 Sussex University Molecular Microbiology Group 1997/ 6 至1998/7
論文發表 1.   Peter Yuk-Fong Liu, Yeu-Jun Lau, Bor-Shen Hu, Jainn-Ming Shir, Man-Han Cheung, Zhi-Yuan Shi, and Wen-Shih Tsai, 1994, Use of PCR to study epidemiology of Serratia marcescens isolates in nosocomial infection. J. Clin. Microbiol. 32:1935-1938.
2.   Peter Yuk-Fong Liu, Zhi-Yuan Shi, Yeu-Jun Lau, and Bor-shen Hu, 1994, Rapid diagnosis of tuberculous meningitis by a simplified nested amplification protocol. Neurology 44:1161-1164.
3.   Yeu-Jun Lau, Peter Yuk-Fong Liu, Bor-Shen Hu, Jainn-Ming Shir, Zhi-Yuan Shi, Wen-Shih Tsai, Yu-Hui Lin, and Ching-Yu Tseng, 1995, DNA fingerprinting of Pseudomonas aeruginosa serotype O11 by enterobacterial intergenic consensus-polymerase chain reaction and pulsed-field electrophoresis. J. Hosp. Infect. 31:61-66.
4.   Peter Yuk-Fong Liu, Yeu-Jun Lau, Bor-Shen Hu, Jainn-Ming Shyr, Zhi-Yuan Shi, Wen-Shih Tsai, Yu-Hui Lin, and Ching-Yu Tseng, 1995, Analysis of clonal relationships among isolates of Shigella sonnei by different molecular typing methods. J. Clin. Microbiol. 33:1779-1783.
5.   Peter Yuk-Fong Liu, Zhi-Yuan Shi, Yeu-Jun Lau, Bor-Shen Hu, Jainn-Ming Shyr, Wen-Shih Tsai, Yu-Hui Lin, and Ching-Yu Tseng, 1995, Comparison of different PCR approaches for characterization of Burkholderia (Pseudomonas) cepacia isolates. J. Clin. Microbiol. 33:3304-3307.
6.   Yu-Hui Lin, P.Y.F. Liu, Bor-Shen Hu, Yeu-Jun Lau., Wen-Shih Tsai, Zhi-Yuan Shi, Jainn-Ming Shir and Man-Han Cheung, 1995, In vitro activity of cefepime in comparison with those of other cephalosporins. J. Infect. Dis. Soc. ROC. 4:1-11.
7.   Peter Yuk-Fong Liu, Zhi-Yuan Shi, Yeu-Jun Lau and Bor-Shen Hu, 1995, Tuberculous meningitis. Neurology 45:1425-1426.
8.   Peter Yuk-Fong Liu, Zhi-Yuan Shi, Yeu-Jun Lau, Bor-Shen Hu, Jainn-Ming Shyr, Wen-Shih Tsai, Yu-Hui Lin, and Ching-Yu Tseng, 1996, Use of restriction endonuclease of plasmids and pulsed-field gel electrophoresis to investigate outbreaks of methicillin-resistant Staphylococcus aureus. Clin. Infect. Dis. 22:86-90.
9.   Peter Yuk-Fong Liu, Zhi-Yuan Shi, Yeu-Jun Lau, Bor-Shen Hu, Jainn-Ming Shyr, Wen-Shih Tsai, Yu-Hui Lin, and Ching-Yu Tseng, 1996, Molecular analysis f Burkholderia (Pseudomonas) cepacia: Differentiation between relapse and reinfection in a case of recurrent bacteremia. Clin, Infect. Dis. 22:584-586.
10.      Peter Yuk-Fong Liu, Zhi-Yuan Shi, Yeu-Jun Lau, Bor-shen Hu, Jainn-Ming Shyr, Wen-Shih Tsai, Yu-Hui Lin, and Ching-Yu Tseng, 1996, Epidemiological typing of Flavimonas oryzhabitans by PCR and pulsed-field gel electrophoresis. J. Clin. Microbiol. 34:68-70.
11.      Zhi-Yuan Shi, Peter Yuk-Fong Liu, Yeu-Jun Lau, Yu-Hui Lin, Bor-Shen Hu, and Jainn-Ming Shir, 1996, Antimicrobial susceptibility of clinical isolates of Acinetobacter baumannii. Diag. Microbiol. Infect. Dis. 24:81-85.
12.      Zhi-Yuan Shi, Peter Yuk-Fong Liu, Yeu-Jun Lau, Yu-His Lin, and Bor-Shen Hu, 1996, Epidemiological typing of isolates from an outbreak of infection with multidrug-resistant Enterobacter cloacae by reptitive extragenic palindromic unit b1-primed PCR and pulsed-field gel electrophoresis. J. Clin. Microbiol. 34:2784-2790.
13.      Zhi-Yuan Shi, Peter Yuk-Fong Liu, Yeu-Jun Lau, Bor-Shen Hu, and Yu-Hui Lin, 1996, Comparison of polymerase chain reaction and pulsed-field gel electrophoresis for the epidemiological typing of Campylobacter jejuni. Diag. Microbiol. Infect. Dis. 26:103-108.
14.      Yu-Hui Lin, PeterYuk-Fong Liu, Zhi-Yuan Shi, Yeu-Jun Lau, and Bor-shen Hu, 1997, Comparison of polymerase chain reaction and pulsed –field gel electrophoresis for the epidemiological typing of Alcaligenes xylosoxidans subsp. xylosoxidans in a burn unit. Diag. Microbiol. Infect. Dis. 28:173-178.
15.      Zhi-Yuan Shi, Peter Yuk-Fong Liu, Yeu-Jun Lau, Bor-shen Hu, and Yu-Hui Lin, 1997, Use of pulsed-field gel electrophoresis to investigate and outbreak of Serratia marcescens. J. Clin. Microbiol. 35:325-327.
16.      Zhi-Yuan Shi, Mark C. Enright, Paul Wilkinson, David Griffiths, and Brian G. Spratt, 1998, Identification of three major clones of multiply antibiotic-resistant Streptococcus pneumoniae in Taiwanese hospitals by multilocus sequencing typing. J. Clin. Microbiol. 36:3514-3519.
17.      Bor-Shen Hu, Yeu-Jun Lau, Zhi-Yuan Shi, Yu-Hui Lin, 1999, Necrotizing fasciitis associated with Klebsiella pneumoniae liver abscess. Clin. Infect. Dis.29:1360-1361..
18.      Yeu-Jun Lau, Bor-Shen Hu, Wan-Ling Wu, Yu-Hui Lin, Hwan-You Chang, Zhi-yuan Shi, 2000, Identification of a major cluster of Klebsiella pneumoniae isolates from patients with liver abscess in Taiwan. J. Clin. Microbiol.1:412-414.
19.      Dah-Hsing Tzeng, Ya-Ling Lee, Yu-Hui Lin, Chen-AnTsai, Zhi-Yuan Shi, Diagnostic value for the Binax NOW Assay for identifying a pneumococcal etiology in patients with respiratory tract infection. J. Microbiol. Immunol. Infect. 2006; 39:39-44.
20.       Ya-Ling Lee1, Po-Pin Hung, Che-An Tsai, Yu-Hui Lin,Chun-Eng Liu, Zi-Yuan Shi, Clinical characteristics of non-O1/non-O139 Vibrio cholerae isolates and their virulence factors analyzed by PCR   J. Microbiol. Immunol. Infect. 2007 40(6): 474-480.
21.      Po-Pin Hung, Yu-Hui Lin, Chin-Fu Lin, Meei-Fang Liu, Zhi-Yuan Shi, 2008, Chryseobacterium meningosepticum infection: antibiotic susceptibility and risk factors for mortality J. Microbiol. Immunol. Infect. 41:137-144
22.      Chi-Jen Chung, Hsin-I Lin, Hsi-Kai Tsou, Zhi-Yuan Shi, Ju-Liang He, An Antimicrobial TiO2Coating for Reducing Hospital-Acquired Infection . J Biomed Mater Res Part B: Appl Biomater 85B: 220–224, 2008
23.      Tsi-Shu Huang, Susan Shin-Jung Lee, Po-Ren Hsueh, Hung-Chin Tsai, Yao-Shen Chen,Shue-Ren Wann, Hsieh-Shong Leu, 5Wen-Chien Ko, Jing-Jou Yan, Shi-Zhi Yuan, Feng-Yee Chang, Jang-Jih Lu, Jen-Hsien Wang, Hua-Kung Wang, Yung-Ching Liu, Antimicrobial Resistance of Rapidly Growing Mycobacteria in Western Taiwan: SMART Program 2002 J Formos Med Assoc 1 (2008) 107 No 4
24.      Pei-Yi Yu, Yusen Eason Lin, Wei-Ru Lin, Hsiu-Yun Shih, Yin-Ching Chuang, Ren-Jy Ben,  Wen-Kuei Huang, Yao-Shen Chen, Yung-Ching Liu, Feng-Yee Chang, Muh-Yong Yen, Ching-Chuan Liu, Wen-Chien Ko, Hsi-Hsun Lin, Zhi-Yuan Shi, The high prevalence of Legionella pneumophilacontamination in hospital potable water systems in Taiwan: implications for hospital infection control in Asia International Journal of Infectious Diseases 2008; 12: 416—420
25.      Jien-Wei Liu, Lih-Shinn Wang, Yu-Jen Cheng, Gwo-Jong Hsu, Po-Liang Lu, Yung-Ching Liu,Chih-Ming Chen, Chun-Ming Lee, Wu Sun, Tsrang-Neng Jang, Ping-Cherng Chiang, Yin-Ching Chuang, Hsiu-Chen Lin, Zhi-Yuan Shi, Hsiang-Chi Kung, Cheng-Hua Huang, Shih-Ming Tsao, Chin-Te Lu, Chun-Hsing Liao, Po-Ren Hsueh, In-vitro activity of tigecycline against clinical isolates of Acinetobacter baumannii in Taiwan International Journal of Antimicrobial Agents 32, S3 (2008) S188-S191
26.      Shih-Ming Tsao, Hsiu-Chen Lin, Chun-Ming Lee, Gwo-Jong Hsu, Chih-Ming Chen, Wu Sun,Yung-Ching Liu, Tsrang-Neng Jang, Yu-Jen Cheng, Po-Liang Lu, Ping-Chreng Chiang, Lih-Shinn Wang, Hsiang-Chi Kung, Yin-Ching Chuang, Zhi-Yuan Shi, Jien-Wei Liu, Cheng-Hua Huang, Chin-Te Lu, Chun-Hsing Liao, Po-Ren Hsueh, Nationwide surveillance in Taiwan of the in-vitro activity of tigecycline against clinical isolates of Gram-positive cocci International Journal of Antimicrobial Agents 32, S3 (2008) S184-S187
27.      Chun-Hsing Liao, Hsiang-Chi Kung, Gwo-Jong Hsu, Po-Liang Lu, Yung-Ching Liu, Chih-Ming Chen, Chun-Ming Lee, Wu Sun, Tsrang-Neng Jang, Ping-Cherng Chiang, Yu-Jen Cheng, Hsiu-Chen Lin, Zhi-Yuan Shi, Lih-Shinn Wang, Yin-Ching Chuang, Shih-Ming Tsao, Chin-Te Lu, Jien-Wei Liu, Cheng-Hua Huang, Po-Ren Hsueh, In-vitro activity of tigecycline against clinical isolates of Acinetobacter baumannii in Taiwan determined by the broth microdilution and disk diffusion methods International Journal of Antimicrobial Agents 32, S3 (2008) S192-S196
28.      Chin-Te Lu, Yin-Ching Chuang, Wu Sun, Yung-Ching Liu, Yu-Jen Cheng, Po-Liang Lu, Chih-Ming Chen, Gwo-Jong Hsu, Tsrang-Neng Jang, Chun-Ming Lee, Ping-Cherng Chiang, Zhi-Yuan Shi, Lih-Shinn Wang, Hsiang-Chi Kung, Hsiu-Chen Lin, Chun-Hsing Liao, Jien-Wei Liu, Cheng-Hua Huang, Shih-Ming Tsao, Po-Ren Hsueh, Nationwide surveillance in Taiwan of the in-vitro activityof tigecycline against clinical isolates of extended-spectrum b-lactamase-producing Enterobacteriaceae Journal of Antimicrobial Agents 32, S3 (2008) S179-S183
29.      Chi-Jen Chung, Hsin-I Lin, Chia-Man Chou, Ping-Yen Hsieh, Ching-Hung Hsiao, Zhi-Yuan Shi, Ju-Liang,  He Inactivation of Staphylococcus aureus and Escherichia coli under various light sources on photocatalytic titanium dioxide thin film Surface & Coatings Technology 203 (2009) 1081-1085
30.      Po-Yu Liu, Youngsen Yang, Zhi-Yaun Shi, Cryptococcal Liver Abscess: a Case Report of Successful Treatment with Amphotericin-B and Literature Review 62,Jpn.J.Infetc.Dis.(2009)59-60
31.      Chih-Chauan Kao, Meei-Fang Liu, Chin-Fu Lin, Yi-Ching Huang, Po-Yu Liu, Ching-Wen Chang, Zhi-Yuan Shi, Antimicrobial Susceptibility and Multiplex PCR Screening of AmpC Genes From Isolates of Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens, J Microbiol Immunol Infect 2010; 43(3): 180–187
32.      Yi-Ching Huang, Meei-Fang Liu, Gwan-Han Shen, Chin-Fu Lin, Chih-Chuan Kao, Po-Yu Liu, Zhi-Yuan Shi,  Clinical Outcome of Mycobacterium abscessus Infection and Antimicrobial Susceptibility Testing, J Microbiol Immunol Infect 2010; 43 (5): 401–406
33.      Po-Yu Liu, Yuang Sen Tsuei, Zhi-Yaun Shi, Multidrug-resistant Acinetobacter baumannii brain abscess, J. Neurosurg 2010;112 (1): 216
34.      Chien-Feng Li , Meei-Fang Liu, Zhi-Yuan Shi    Changing Trend of Antimicrobial Susceptibility of Streptococcus pneumoniae isolates in Taiwan, 2006—2007.  2012; 45: 305-310
35.      Moan-Shane Tsai, Yun-Liang Yang, An-Huei Wang, Lih-Shinn Wang, Daniel C. T. Lu, Ci-Hong Liou, Li-Yun Hsieh, Chi-Jung Wu, Ming-Fang Cheng, Zhi-Yuan Shi, Hsiu-Jung Lo, Susceptibilities to Amphotericin B, Fluconazoleand Voriconazole of Trichosporon Clinical Isolates:Mycopathologia DOI 10.1007/s11046-012-9525-z
36.      Shih-Ping Lin a, Meei-Fang Liu a, Chin-Fu Lin b, Zhi-Yuan Shi a,c,  Phenotypic detection and polymerase chain reaction screening of extended-spectrum β-lactamases produced by Pseudomonas aeruginosa isolatesl:Journal of Microbiology, Immunology and Infection 2012; 45: 200-207
37.      Ping-Yun Huang1, Zhi-Yuan Shi2, Chi-Hao Chen1, Walter Den1*, Hui-Mei Huang3, Jaw-Ji Tsai4 , Airborne and Surface-Bound Microbial Contamination in Two Intensive Care Units of a Medical Center in Central Taiwan , Aerosol and Air Quality Research, 2013; 13: 1060–1069
38.      Shu-Ting Tseng, Chun-Hsi Tai a, Chia-Ru Li a, Chin-Fu Lin c, Zhi-Yuan Shi a,b,* ,
The mutations of katG and inhA genes of isoniazid-resistant Mycobacterium tuberculosis isolates in Taiwan:Journal of Microbiology, Immunology and Infection DOI: 10.1016/j.jmii.2013.08.018
39.      Sz-Rung Huang a, Meei-Fang Liu a, Chin-Fu Lin c, Zhi-Yuan Shi a,b,*,
Molecular surveillance and clinical outcomes of carbapenem-resistant Escherichia coli and Klebsiella pneumonia infections:Journal of Microbiology, Immunology and Infection  2014; 47: 187-196
40.      Yun-Ho Lin a, Chun-Hsi Taia, Chia-Ru Li a, Chin-Fu Lin c, Zhi-Yuan Shia,b,*,
Resistance profiles and rpoB gene mutations of Mycobacterium tuberculosis isolates in Taiwan:Journal of Microbiology, Immunology and Infection 2013; 46: 266-270
41.      Yun-Ho Lin1, Yu-Hui Lin2, and Zhi-Yuan Shi2,3*. A Case Report of Scrub Typhus-Associated Hemophagocytic Syndrome and a Review of Literature:Jpn. J. Infect. Dis. 2014; 67:115-117.
42.      Yung-Chun Chen , Ching-Heng Lin , Shih-Ni Chang , Zhi-Yuan Shi .Epidemiology and clinical outcome of pyogenic liver abscess: an analysis from the National Health Insurance Research Database of Taiwan, 2000e2011 : Journal of Microbiology, Immunology and Infection (2014) xx, 1e8    (SCI: 2.349)
陳永俊、林敬恆、張仕妮、施智源
肝膿瘍之健保資料庫分析
43.      Chia-Hui Chuang , Meei-Fang Liu , Chin-Fu Lin , Zhi-Yuan Shi  .Impact of revised susceptibility breakpoints on bacteremia of Klebsiella pneumoniae: Minimum inhibitory concentration of cefazolin and clinical outcomes : Journal of Microbiology, Immunology and Infection (2014) xx, 1e6   (SCI: 2.349)
莊佳慧、劉美芳、林進福、施智源  
 肺炎克雷伯菌菌血症治療的影響
44.      陳正斌、劉美芳、林進福、林詩萍、施智源
The association of molecular typing, vancomycin MIC, and clinical outcome for patients with methicillin-resistant Staphylococcus aureus infections : Journal of Microbiology, Immunology and Infection
45.      王功錦、林進福、劉美芳、施智源
 The impact of revised cefazolin CLSI breakpoint on outcome of patients with E. coli bacteremia : Journal of Microbiology, Immunology and Infection
46.      陳瀅淳、劉美芳、施智源(2006) ·生物膜在泌尿道感染中所扮演的角色及相關處置 ·感染控制雜誌,16(1):43-46。
47.      施智源、陳瀅淳、劉美芳 (2007)·美國疾病管制中心2004年院內感染定義中譯 ·感染控制雜誌,17(1):11-44。
48.      陳瀅淳、施智源、傅任云婕、劉美容、張綠娟、丘愛平、王凱君(2007)·導尿管使用之原因與留置天數分析 ·台灣醫學,11(4): 345-351。
49.      劉伯瑜、施智源 (2007) ·多重抗藥性鮑氏不動桿菌的相關因子及感染管制策略 ·感染控制雜誌, 17 (1):45-50
50.      施智源、曾淑婷 (2009) 退伍軍人菌之消毒方法 ·感控雜誌 19(3):168-174
51.      施智源、黃怡文、黃芳亮 (2009) 益生菌的臨床應用:文獻回顧 ·感控雜誌 19(3) 182-188
52.      施智源、劉伯瑜 (2009) 不同國家間醫療照護相關感染盛行率的比較 ·感控雜誌 19(3) 194-195
53.      施智源、陳冠儒 (2009) 臭氧是有效的抗菌劑 ·感控雜誌 19(3) 196-19854.      林芸合、施智源、許惠恒 (2012) ·糖尿病與泌尿道感染新進展 · 內科學誌 23(3):173-182
54.      林芸合、施智源、許惠恒 (2012) ·糖尿病與泌尿道感染新進展 · 內科學誌 23(3):173-182